Postdoctoral Research Scientist (Immune Cell Signalling) at Babraham Institute
Job Description
The Babraham Institute is a charity which is world renowned for its research in life sciences to enhance lives and improve wellbeing.
We are seeking an enthusiastic Postdoctoral Research scientist with a background in immunology, redox biology, mechanobiology, or signalling and an interest in molecular mechanisms of T cell activation to join the group of Dr Hayley Sharpe at the Babraham Institute.
The Sharpe lab is interested in the cross talk between second messenger hydrogen peroxide signalling and the phosphotyrosine machinery in our cells. This ERC funded project will investigate how antigen binding to T cell receptors elicits rapid responses, initiated by tyrosine phosphorylation. This will not only give us new insights into T cell function, but also has implications for T cell based therapies (such as CAR-T approaches) and other analogous receptor paradigms.
The candidate will play a central role in driving this project forward using experimental models developed by the laboratory. The candidate will identify how and when hydrogen peroxide is generated proximal to the plasma membrane. This will build on and aim to validate our preliminary data that this is a rapid response. The project will explore the implications and molecular targets of hydrogen peroxide, with scope for understanding graded signalling as well as in vivo responses.
We are a highly collaborative team within the Signalling programme at the Babraham Institute, with close ties to colleagues in our Immunology department. Our approaches range from biochemistry to cell biology to in vivo models, ideally using insights from protein-centric studies to understand physiological processes.
The Babraham Institute is world-renowned for its research in life sciences and the post-holder will benefit from world-class research facilities, the collegial environment of the Institute and the wider scientific research community in the Cambridge area.
The ideal candidate will hold a PhD in Biochemistry, molecular/cell Biology, immunology or a relevant subject; and their expertise may include research experience with signalling, redox biology, immunology, mechanobiology and/or cell imaging.
This is a limited term appointment with funding for this post available for a period of 3 years in the first instance.
For more information on the work of the group, please visit:
https://www.babraham.ac.uk/our-research/signalling/hayley-sharpe
https://www.babraham.ac.uk/news/2023/11/hayley-sharpe-receives-erc-consolidator-grant
Applicants must hold a PhD or have their thesis submitted when commencing the post. Please note that you will be appointed on the starting salary of £33,500 per annum, if you have not yet been awarded your PhD.
Closing date for applications is 8th April 2024. However, we reserve the right to close the vacancy early depending on the volume of applications received.
For further details about this position or to apply online visit here.
Further information about the Institute can also be found on our website (www.babraham.ac.uk).
The Babraham Institute welcomes applications from all sections of society.
NO AGENCIES PLEASE
The Babraham Institute holds a silver Athena SWAN award and is committed to promoting and developing a culture of excellence, diversity and mutual respect that supports the Institute’s ambitions and attracts highly motivated and talented people.
The Babraham Institute abides by the principles of the government’s Disability Confident Scheme and has a positive approach to employing disabled people.
The Babraham Institute receives strategic funding from the Biotechnology and Biological Sciences Research Council and is an Equal Opportunities Employer.
